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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2325584
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mir34a
Name: microRNA 34a
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir34adecreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of MIR34A mRNAPMID:35378083
Mir34amultiple interactionsEXP 6480464CTD[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate] affects the expression of MIR34A; Benzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in decreased expression of MIR34A mRNA]; Dibutyl Phthalate promotes the reaction [Benzo(a)pyrene results in decreased expression of MIR34A mRNA]PMID:35378083 PMID:36226823
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