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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of CAT mRNAPMID:21266533 PMID:32525071
Catincreases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of CAT mRNA; Dibutyl Phthalate results in increased expression of CAT proteinPMID:24893172 PMID:25172463
Catmultiple interactionsEXP 6480464CTDtaxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]PMID:32525071
Catincreases activityISOCat (Mus musculus)6480464CTDDibutyl Phthalate results in increased activity of CAT proteinPMID:37277016
Catmultiple interactionsISOCat (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CAT mRNA; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CAT protein]PMID:28013214 PMID:37277016
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