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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606587
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP19A1decreases activityEXP 6480464CTDDibutyl Phthalate results in decreased activity of CYP19A1 proteinPMID:27825933
CYP19A1decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of CYP19A1 mRNAPMID:28104404
CYP19A1decreases expressionISOCyp19a1 (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of CYP19A1 mRNAPMID:29029336
CYP19A1increases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in increased expression of CYP19A1 mRNAPMID:19560483
CYP19A1increases expressionISOCyp19a1 (Mus musculus)6480464CTDDibutyl Phthalate results in increased expression of CYP19A1 mRNAPMID:25765776
CYP19A1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTD[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP19A1 mRNAPMID:25607892
CYP19A1multiple interactionsISOCyp19a1 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 protein; [Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate] results in decreased expression of CYP19A1 mRNAPMID:28013214 PMID:29029336 PMID:34597818
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