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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Adecreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDDibutyl Phthalate results in decreased expression of PPARGC1A proteinPMID:32525071
PPARGC1Aincreases expressionISOPpargc1a (Mus musculus)6480464CTDDibutyl Phthalate results in increased expression of PPARGC1A mRNAPMID:17361019 PMID:21266533
PPARGC1Amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with Diethylhexyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased expression of PPARGC1A mRNAPMID:37021957
PPARGC1Amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDtaxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]PMID:32525071
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