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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10127
Species: Mus musculus
RGD Object: Gene
Symbol: Ahr
Name: aryl-hydrocarbon receptor
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects activityEXP 6480464CTDDibutyl Phthalate affects the activity of AHR proteinPMID:18294747
Ahrdecreases expressionISOAhr (Rattus norvegicus)6480464CTDDibutyl Phthalate results in decreased expression of AHR mRNAPMID:24893172
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDDibutyl Phthalate binds to and results in increased activity of AHR proteinPMID:23220035
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