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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727821
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nit1
Name: nitrilase 1
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDiazinon results in decreased expression of NIT1 protein

PMID:26721910
increases methylationISORGD:13497516480464CTDDiazinon results in increased methylation of NIT1 gene

PMID:22964155
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.