Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1346266
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	FAS
Name:	Fas cell surface death receptor

Acc ID:	CHEBI:34682
Term:	diazinon
Definition:	A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID:	MESH:D003976

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
FAS	increases expression	EXP		6480464	CTD	Diazinon results in increased expression of FAS mRNA	PMID:27920530
FAS	multiple interactions	EXP		6480464	CTD	[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of FAS mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of FAS mRNA]; Selenium analog inhibits the reaction [Diazinon results in increased expression of FAS mRNA]	PMID:27920530
FAS	affects expression	ISO	Fas (Rattus norvegicus)	6480464	CTD	Diazinon affects the expression of FAS mRNA	PMID:22546817
FAS	increases expression	ISO	Fas (Mus musculus)	6480464	CTD	Diazinon results in increased expression of FAS mRNA	PMID:33872936
FAS	multiple interactions	ISO	Fas (Mus musculus)	6480464	CTD	Fulvestrant inhibits the reaction [Diazinon results in increased expression of FAS mRNA]	PMID:33872936

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