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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:34680
Term: dipentyl phthalate
Definition: A phthalate ester that is the dipentyl ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C034171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:692136480464CTDdi-n-pentyl phthalate analog binds to ESR2 protein

PMID:15464722
multiple interactionsISORGD:692136480464CTDdi-n-pentyl phthalate binds to and results in decreased activity of ESR2 protein, di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

PMID:15840436, PMID:28571686
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.