GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | affects binding | EXP | | 6480464 | CTD | di-n-hexyl phthalate analog binds to ESR1 protein | PMID:15464722 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein] | PMID:15840436 PMID:28571686 | ESR1 | increases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | di-n-hexyl phthalate results in increased expression of ESR1 mRNA | PMID:22112501 | | ||||||||||||||||||||||
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