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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:34665
Term: debrisoquin
Definition: A carboxamidine that has formula C10H13N3.
Chemical ID: MESH:D003647
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein affects the metabolism of Debrisoquin; CYP2D6 protein polymorphism affects the metabolism of DebrisoquinPMID:11823760 PMID:3577206
Cyp2d4decreases metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; CYP2D6 gene polymorphism results in decreased metabolism of DebrisoquinPMID:6603386 PMID:8946814
Cyp2d4decreases response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form results in decreased susceptibility to DebrisoquinPMID:11673748
Cyp2d4increases abundanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolitePMID:11673748
Cyp2d4increases hydroxylationISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in increased hydroxylation of DebrisoquinPMID:17470523
Cyp2d4increases metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in increased metabolism of DebrisoquinPMID:12464242
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]PMID:11673748
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