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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603864
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP4A22
Name: cytochrome P450 family 4 subfamily A member 22
Acc ID: CHEBI:34648
Term: clofibric acid
Definition: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Chemical ID: MESH:D002995
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP4A22increases expressionISOCyp4a1 (Rattus norvegicus)6480464CTDClofibric Acid results in increased expression of CYP4A1 mRNAPMID:15670589
CYP4A22multiple interactionsISOCyp4a1 (Rattus norvegicus)6480464CTDClofibric Acid results in increased expression of and results in increased activity of CYP4A1 proteinPMID:15946133
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