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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733240
Species: Mus musculus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1affects response to substanceEXP 6480464CTDPON1 protein affects the susceptibility to ChlorpyrifosPMID:32976529
Pon1decreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of PON1 mRNAPMID:29404631
Pon1increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of PON1 mRNAPMID:32715474
Pon1increases response to substanceEXP 6480464CTDPON1 gene mutant form results in increased susceptibility to ChlorpyrifosPMID:11022865
Pon1multiple interactionsEXP 6480464CTD[APOE protein results in increased susceptibility to Chlorpyrifos] which results in decreased expression of PON1 mRNAPMID:29404631
Pon1affects expressionISOPON1 (Homo sapiens)6480464CTDChlorpyrifos affects the expression of PON1 mRNAPMID:26948828
Pon1affects metabolic processingISOPON1 (Homo sapiens)6480464CTDPON1 protein affects the metabolism of ChlorpyrifosPMID:16002382
Pon1affects response to substanceISOPON1 (Homo sapiens)6480464CTDPON1 gene polymorphism affects the susceptibility to Chlorpyrifos; PON1 protein polymorphism affects the susceptibility to ChlorpyrifosPMID:19907334 PMID:31981688
Pon1decreases expressionISOPon1 (Rattus norvegicus)6480464CTDChlorpyrifos results in decreased expression of PON1 mRNA; Chlorpyrifos results in decreased expression of PON1 proteinPMID:31400774
Pon1increases hydrolysisISOPON1 (Homo sapiens)6480464CTDPON1 protein results in increased hydrolysis of ChlorpyrifosPMID:16331452
Pon1increases response to substanceISOPON1 (Homo sapiens)6480464CTDPON1 protein polymorphism results in increased susceptibility to Chlorpyrifos; PON1 protein results in increased susceptibility to ChlorpyrifosPMID:16007003 PMID:20176005
Pon1multiple interactionsISOPON1 (Homo sapiens)6480464CTDChlorpyrifos affects the expression of and results in increased activity of PON1 protein; PON1 protein polymorphism inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]PMID:26948828 PMID:31981688
Pon1multiple interactionsISOPon1 (Rattus norvegicus)6480464CTD[Propolis co-treated with Chlorpyrifos co-treated with Streptozocin] results in decreased expression of PON1 mRNA; [Propolis co-treated with Chlorpyrifos co-treated with Streptozocin] results in decreased expression of PON1 protein; [Propolis co-treated with Chlorpyrifos] results in decreased expression of PON1 mRNA; [Propolis co-treated with Chlorpyrifos] results in decreased expression of PON1 protein; [Streptozocin co-treated with Chlorpyrifos] inhibits the reaction [Propolis results in increased expression of PON1 mRNA]; [Streptozocin co-treated with Chlorpyrifos] inhibits the reaction [Propolis results in increased expression of PON1 protein]; [Streptozocin co-treated with Chlorpyrifos] results in decreased expression of PON1 mRNA; [Streptozocin co-treated with Chlorpyrifos] results in decreased expression of PON1 protein; Chlorpyrifos inhibits the reaction [Propolis results in increased expression of PON1 mRNA]; Chlorpyrifos inhibits the reaction [Propolis results in increased expression of PON1 protein]; Chlorpyrifos inhibits the reaction [Streptozocin results in decreased expression of PON1 protein]; Chlorpyrifos promotes the reaction [Streptozocin results in decreased expression of PON1 mRNA]; Propolis inhibits the reaction [[Streptozocin co-treated with Chlorpyrifos] results in decreased expression of PON1 mRNA]; Propolis inhibits the reaction [[Streptozocin co-treated with Chlorpyrifos] results in decreased expression of PON1 protein]; Propolis inhibits the reaction [Chlorpyrifos results in decreased expression of PON1 mRNA]; Propolis inhibits the reaction [Chlorpyrifos results in decreased expression of PON1 protein]; Streptozocin inhibits the reaction [Chlorpyrifos results in decreased expression of PON1 protein]; Streptozocin promotes the reaction [Chlorpyrifos results in decreased expression of PON1 mRNA]PMID:31400774
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