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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731729
Species: Mus musculus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of CASP1 mRNAPMID:27737797 PMID:29156651
Casp1multiple interactionsEXP 6480464CTD[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in decreased expression of CASP1 mRNAPMID:22515965
Casp1increases cleavageISOCASP1 (Homo sapiens)6480464CTDChlorpyrifos results in increased cleavage of CASP1 proteinPMID:30835941
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of CASP1 mRNA; Chlorpyrifos results in increased expression of CASP1 proteinPMID:26435000 PMID:30835941
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of CASP1 protein]; MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of CASP1 protein]; NFE2L2 protein inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP1 protein]; NFE2L2 protein inhibits the reaction [Chlorpyrifos results in increased expression of CASP1 mRNA]PMID:26435000 PMID:30835941
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