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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2affects bindingISONR1I2 (Homo sapiens)6480464CTDChlorpyrifos binds to NR1I2 proteinPMID:36893891
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDChlorpyrifos results in increased activity of NR1I2 proteinPMID:15548381 PMID:28728110
Nr1i2increases expressionISONR1I2 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of NR1I2 mRNAPMID:36893891
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDChlorpyrifos binds to and results in increased activity of NR1I2 protein; Chlorpyrifos promotes the reaction [NR1I2 protein results in increased expression of CYP3A4]PMID:16054614 PMID:21115097 PMID:36893891
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDChlorpyrifos binds to and results in increased activity of NR1I2 proteinPMID:21115097
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