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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfaffects expressionEXP 6480464CTDChlorpyrifos affects the expression of BDNF mRNAPMID:18502319
Bdnfdecreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of BDNF mRNAPMID:32387648
Bdnfincreases expressionEXP 6480464CTDChlorpyrifos results in increased expression of BDNF mRNA; Chlorpyrifos results in increased expression of BDNF proteinPMID:17893397 PMID:26775027
Bdnfincreases expressionISOBDNF (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of BDNF proteinPMID:33011216
Bdnfmultiple interactionsISOBDNF (Homo sapiens)6480464CTD[Chlorpyrifos co-treated with BDNF protein] results in decreased activity of ACHE protein; Chlorpyrifos inhibits the reaction [BDNF protein results in increased activity of BCHE protein]PMID:30200437
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