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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344163
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I3
Name: nuclear receptor subfamily 1 group I member 3
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I3increases activityEXP 6480464CTDChlorpyrifos results in increased activity of NR1I3 proteinPMID:28927721
NR1I3increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of NR1I3 mRNAPMID:22310298
NR1I3increases expressionISONr1i3 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of NR1I3 mRNAPMID:22310298
NR1I3multiple interactionsISONr1i3 (Mus musculus)6480464CTDChlorpyrifos binds to and results in increased activity of NR1I3 protein; Chlorpyrifos inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram]PMID:18832183 PMID:29950287
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