GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp19a1 | decreases expression | EXP | | 6480464 | CTD | butylbenzyl phthalate results in decreased expression of CYP19A1 mRNA; butylbenzyl phthalate results in decreased expression of CYP19A1 protein | PMID:29029336 | Cyp19a1 | increases expression | EXP | | 6480464 | CTD | butylbenzyl phthalate results in increased expression of CYP19A1 mRNA; butylbenzyl phthalate results in increased expression of CYP19A1 protein | PMID:38227285 | Cyp19a1 | multiple interactions | EXP | | 6480464 | CTD | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 protein; [Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate] results in decreased expression of CYP19A1 mRNA; schizandrin B inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP19A1 mRNA]; schizandrin B inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP19A1 protein] | PMID:28013214 PMID:29029336 PMID:34597818 PMID:38227285 | Cyp19a1 | decreases activity | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate results in decreased activity of CYP19A1 protein | PMID:27825933 | Cyp19a1 | multiple interactions | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate results in increased expression of and results in increased activity of CYP19A1 protein; Fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased activity of CYP19A1 protein] | PMID:31016752 | | ||||||||||||||||||||||
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