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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:34595
Term: Butylbenzyl phthalate
Definition: A benzyl ester that has formula C19H20O4.
Chemical ID: MESH:C027561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1amultiple interactionsEXP 6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of CDKN1A mRNA]PMID:33316053
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDbutylbenzyl phthalate results in decreased expression of CDKN1A mRNA; butylbenzyl phthalate results in decreased expression of CDKN1A proteinPMID:29864457 PMID:30243731
Cdkn1amultiple interactionsISOCdkn1a (Rattus norvegicus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CDKN1A mRNAPMID:35762964
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDMIR19A mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of CDKN1A protein]; MIR19B1 mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of CDKN1A protein]; MIR34A mRNA inhibits the reaction [butylbenzyl phthalate results in decreased expression of CDKN1A protein]PMID:29864457 PMID:30243731
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