GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2D6 | affects metabolic processing | EXP | | 6480464 | CTD | CYP2D6 protein affects the metabolism of bufuralol | PMID:15801540 | CYP2D6 | increases hydrolysis | EXP | | 6480464 | CTD | CYP2D6 protein results in increased hydrolysis of bufuralol | PMID:11377097 | CYP2D6 | increases hydroxylation | EXP | | 6480464 | CTD | CYP2D6 protein results in increased hydroxylation of bufuralol | PMID:10933885 PMID:12433797 PMID:15258107 PMID:15618748 PMID:15860655 PMID:17470523 PMID:29445054 PMID:35748891 PMID:9429232 | CYP2D6 | increases metabolic processing | EXP | | 6480464 | CTD | CYP2D6 protein results in increased metabolism of bufuralol | PMID:12401345 PMID:12464242 PMID:12467917 PMID:12569440 PMID:16049126 PMID:25084468 PMID:28762043 | CYP2D6 | increases oxidation | EXP | | 6480464 | CTD | CYP2D6 protein results in increased oxidation of bufuralol | PMID:21964418 | CYP2D6 | multiple interactions | EXP | | 6480464 | CTD | 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol]; [CYP2D6 protein results in increased metabolism of bufuralol] which results in increased chemical synthesis of Ro 03-7410; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; perfluorooctane sulfonic acid inhibits the reaction [CYP2D6 protein results in increased oxidation of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; rabeprazole-thioether inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] | PMID:11377097 PMID:12569440 PMID:15258107 PMID:15618748 PMID:16049126 PMID:21964418 PMID:25084468 | CYP2D6 | affects metabolic processing | ISO | Cyp2d4 (Rattus norvegicus) | 6480464 | CTD | CYP2D6 protein affects the metabolism of bufuralol | PMID:15801540 | CYP2D6 | increases hydroxylation | ISO | Cyp2d22 (Mus musculus) | 6480464 | CTD | CYP2D4 protein results in increased hydroxylation of bufuralol | PMID:15742976 | | ||||||||||||||||||||||
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