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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10451
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:34591
Term: bromodichloromethane
Definition: A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.
Chemical ID: MESH:C025191
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases response to substanceEXP 6480464CTDCYP2E1 gene mutant form results in decreased susceptibility to bromodichloromethanePMID:23640861
Cyp2e1multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CYP2E1 protein; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]PMID:23438451 PMID:24211274
Cyp2e1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDbromodichloromethane results in increased expression of CYP2E1 proteinPMID:11295256
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of bromodichloromethanePMID:12076521 PMID:12076522 PMID:18350910
Cyp2e1increases metabolic processingISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased metabolism of bromodichloromethanePMID:11295256 PMID:12076521
Cyp2e1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased metabolism of and results in increased activity of bromodichloromethanePMID:9458004
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