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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:34581
Term: Bisphenol B
Definition: A bisphenol that has formula C16H18O2.
Chemical ID: MESH:C492482
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISORGD:691056480464CTDbisphenol B results in increased activity of NR1I2 protein

PMID:22214767, PMID:30582956, PMID:30951782
Nr1i2multiple interactionsISORGD:691056480464CTD4-cumylphenol promotes the reaction [bisphenol B results in increased activity of NR1I2 protein], bisphenol B inhibits the reaction [TO-901317 binds to NR1I2 protein], bisphenol B promotes the reaction [4-cumylphenol results in increased activity of NR1I2 protein]

PMID:22214767, PMID:31195007
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.