Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34581
Term: Bisphenol B
Definition: A bisphenol that has formula C16H18O2.
Chemical ID: MESH:C492482
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityEXP 6480464CTDbisphenol B results in increased activity of ESR1 protein

PMID:11750080, PMID:12504345
Esr1affects activityISORGD:105516480464CTDbisphenol B affects the activity of ESR1 protein

PMID:23611293
Esr1affects bindingISORGD:7365596480464CTDbisphenol B binds to ESR1 protein

PMID:30143207
Esr1decreases expressionISORGD:7365596480464CTDbisphenol B results in decreased expression of ESR1 protein

PMID:24856822
Esr1increases activityISORGD:7365596480464CTDbisphenol B results in increased activity of ESR1 protein

PMID:30582956, PMID:30951782, PMID:31388671
Esr1multiple interactionsISORGD:7365596480464CTDbisphenol B binds to and results in decreased activity of ESR1 protein, bisphenol B binds to and results in increased activity of ESR1 protein, bisphenol B inhibits the reaction [Estradiol binds to ESR1 protein], bisphenol B results in increased activity of and affects the localization of ESR1 protein, Fulvestrant inhibits the reaction [bisphenol B results in increased activity of ESR1 protein]

PMID:21256200, PMID:25012808, PMID:28591870, PMID:29392883, PMID:31195007, PMID:31388671
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.