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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of STAT3 mRNAPMID:28628672
STAT3increases phosphorylationISOStat3 (Mus musculus)6480464CTD4,4'-bisphenol F results in increased phosphorylation of STAT3 proteinPMID:32044397
STAT3multiple interactionsISOStat3 (Mus musculus)6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [4,4'-bisphenol F results in increased phosphorylation of STAT3 protein]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased phosphorylation of STAT3 protein]PMID:32044397
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