Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDbisphenol F binds to ESR1 proteinPMID:31836225
ESR1decreases expressionEXP 6480464CTDbisphenol F results in decreased expression of ESR1 proteinPMID:31995776 PMID:34831106
ESR1increases activityEXP 6480464CTD4,4'-bisphenol F results in increased activity of ESR1 protein; bisphenol F results in increased activity of ESR1 proteinPMID:30582956 PMID:31388671 PMID:36534918
ESR1increases expressionEXP 6480464CTD4,4'-bisphenol F results in increased expression of ESR1 mRNA; 4,4'-bisphenol F results in increased expression of ESR1 proteinPMID:18973785 PMID:30195206
ESR1multiple interactionsEXP 6480464CTD4,4'-bisphenol F binds to and results in increased activity of ESR1 protein; 4,4'-bisphenol F inhibits the reaction [Estradiol binds to ESR1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [4,4'-bisphenol F results in increased expression of ESR1 protein]; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ESR1 protein; bisphenol F binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of ESR1 protein]PMID:15110108 PMID:28591870 PMID:29392883 PMID:30195206 PMID:31195007 PMID:31388671 PMID:31995776
ESR1affects bindingISOEsr1 (Rattus norvegicus)6480464CTD4,4'-bisphenol F binds to ESR1 proteinPMID:27420082
ESR1increases expressionISOEsr1 (Mus musculus)6480464CTD4,4'-bisphenol F results in increased expression of ESR1 mRNAPMID:30196065
Go Back to source page   Continue to Ontology report