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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11415
Species: Mus musculus
RGD Object: Gene
Symbol: Thra
Name: thyroid hormone receptor alpha
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thraaffects bindingISOTHRA (Homo sapiens)6480464CTD4,4'-bisphenol F binds to THRA proteinPMID:29146198
Thradecreases expressionISOThra (Rattus norvegicus)6480464CTD4,4'-bisphenol F results in decreased expression of THRA mRNAPMID:28167136
Thramultiple interactionsISOTHRA (Homo sapiens)6480464CTD4,4'-bisphenol F inhibits the reaction [Triiodothyronine binds to THRA protein]; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of THRA mRNAPMID:28628672 PMID:29146198
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