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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736033
Species: Mus musculus
RGD Object: Gene
Symbol: Col18a1
Name: collagen, type XVIII, alpha 1
Acc ID: CHEBI:34567
Term: benzo[e]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.
Chemical ID: MESH:C026487
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col18a1decreases methylationISOCOL18A1 (Homo sapiens)6480464CTDbenzo(e)pyrene results in decreased methylation of COL18A1 intronPMID:30157460
Col18a1increases methylationISOCOL18A1 (Homo sapiens)6480464CTDbenzo(e)pyrene results in increased methylation of COL18A1 promoterPMID:30157460
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