GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scube1
Name: signal peptide, CUB domain and EGF like domain containing 1
Acc ID: CHEBI:34567
Term: benzo[e]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.
Chemical ID: MESH:C026487
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases methylationISORGD:13191216480464CTDbenzo(e)pyrene results in increased methylation of SCUBE1 exon

benzo(e)pyrene results in increased methylation of SCUBE1 intron

benzo(e)pyrene results in increased methylation of SCUBE1 polyA tail

PMID:30157460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.