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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:34505
Term: 8-epi-prostaglandin F2alpha
Definition: An isoprostane that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.
Chemical ID: MESH:C075750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases abundanceEXP 6480464CTDIL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha

PMID:11530235
Il1bmultiple interactionsEXP 6480464CTDpyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha] Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]

PMID:11530235
Il1bincreases abundanceISORGD:7309816480464CTDIL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha

PMID:19751497
Il1bincreases chemical synthesisISORGD:7309816480464CTDIL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha

PMID:16529823
Il1bmultiple interactionsISORGD:7309816480464CTD1-4-methylsulfonylphenyl-3-trifluoromethyl-5-4-fluorophenylpyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] 6-hydroxy-2 5 7 8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]] Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]

PMID:16529823 PMID:19751497
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