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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Acc ID: CHEBI:34444
Term: 4-tert-butylphenol
Definition: A member of the class of phenols that is phenol substituted with a tert-butyl group at position 4.
Chemical ID: MESH:C006862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3r1multiple interactionsISORGD:7319586480464CTDAcetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]] Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]] Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]] PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species] PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein] PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]

PMID:28836394
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