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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8decreases expressionEXP 6480464CTD4-nonylphenol results in decreased expression of CASP8 mRNAPMID:27087316
Casp8increases expressionEXP 6480464CTD4-nonylphenol results in increased expression of CASP8 mRNAPMID:30228064
Casp8multiple interactionsEXP 6480464CTD4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA]; bisphenol A affects the reaction [4-nonylphenol results in increased expression of CASP8 mRNA]PMID:30228064
Casp8increases cleavageISOCasp8 (Mus musculus)6480464CTD4-nonylphenol results in increased cleavage of CASP8 proteinPMID:22056370
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