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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionEXP 6480464CTD4-nonylphenol results in increased expression of BECN1 mRNA; 4-nonylphenol results in increased expression of BECN1 proteinPMID:26804764 PMID:28041982 PMID:30228064
Becn1multiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]PMID:26804764 PMID:28041982
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