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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2526
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hbegfincreases secretionISOHbegf (Mus musculus)6480464CTD4-nonylphenol results in increased secretion of HBEGF proteinPMID:28703301
Hbegfmultiple interactionsISOHbegf (Mus musculus)6480464CTD3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]PMID:28703301
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