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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:34432
Term: 4-octylphenol
Definition: A member of the class of phenols that is phenol which is substituted at the para- position by an octyl group.
Chemical ID: MESH:C080417
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingEXP 6480464CTD4-octylphenol binds to ESR1 proteinPMID:19913605
Esr1affects localizationEXP 6480464CTD4-octylphenol affects the localization of ESR1 proteinPMID:20950447
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTD4-octylphenol binds to ESR1 proteinPMID:19913605
Esr1increases activityISOEsr1 (Rattus norvegicus)6480464CTD4-octylphenol results in increased activity of ESR1 proteinPMID:18028983
Esr1increases activityISOESR1 (Homo sapiens)6480464CTD4-octylphenol results in increased activity of ESR1 proteinPMID:18028983
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[4-octylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNAPMID:21783566
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