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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34422
Term: biphenyl-4-ol
Definition: A member of the class of hydroxybiphenyls that is biphenyl carrying a hydroxy group at position 4.
Chemical ID: MESH:C019046
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTD4-phenylphenol binds to ESR1 proteinPMID:12753421 PMID:31836225
ESR1increases activityEXP 6480464CTD4-phenylphenol results in increased activity of ESR1 proteinPMID:18028983
ESR1increases expressionEXP 6480464CTD4-phenylphenol results in increased expression of ESR1 mRNAPMID:12737316
ESR1multiple interactionsEXP 6480464CTD4-phenylphenol binds to and results in increased activity of ESR1 proteinPMID:33049310
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTD4-phenylphenol results in increased activity of ESR1 proteinPMID:18028983
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