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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34421
Term: 4-Hydroxybenzophenone
Definition: A benzophenone that has formula C13H10O2.
Chemical ID: MESH:C024292
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityEXP 6480464CTD4-hydroxybenzophenone results in increased activity of ESR1 proteinPMID:12504345
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTD4-hydroxybenzophenone binds to ESR1 proteinPMID:11354909
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD4-hydroxybenzophenone binds to and results in increased activity of ESR1 protein; 4-hydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein]PMID:11354909 PMID:12765246 PMID:16079615
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