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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityISOMmp2 (Rattus norvegicus)6480464CTDcarvedilol results in decreased activity of MMP2 proteinPMID:16310260
Mmp2decreases expressionISOMmp2 (Rattus norvegicus)6480464CTDcarvedilol results in decreased expression of MMP2PMID:20452391
Mmp2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTDcarvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]PMID:16213474
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDcarvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]PMID:17964422
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