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REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 30296650
Species: All species
RGD Object: Reference
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expression EXP 30296650RGDcarvedilol decreases expression of collagen I mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Col3a1decreases expression EXP 30296650RGDcarvedilol decreases expression of collagen III mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Fn1decreases expression EXP 30296650RGDcarvedilol decreases expression of fibronectin mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Tgfb1decreases expression EXP 30296650RGDcarvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
FN1decreases expression ISORGD:262430296650RGDcarvedilol decreases expression of fibronectin mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Fn1decreases expression ISORGD:262430296650RGDcarvedilol decreases expression of fibronectin mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
COL1A1decreases expression ISORGD:6181730296650RGDcarvedilol decreases expression of collagen I mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Col1a1decreases expression ISORGD:6181730296650RGDcarvedilol decreases expression of collagen I mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
TGFB1decreases expression ISORGD:6905130296650RGDcarvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Tgfb1decreases expression ISORGD:6905130296650RGDcarvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
COL3A1decreases expression ISORGD:7102930296650RGDcarvedilol decreases expression of collagen III mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
Col3a1decreases expression ISORGD:7102930296650RGDcarvedilol decreases expression of collagen III mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats

 
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