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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2325457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mir125b1
Name: microRNA 125b-1
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir125b1increases expressionISOMir125b-1 (Mus musculus)6480464CTDcarvedilol results in increased expression of MIR125B-1 mRNAPMID:24334028
Mir125b1multiple interactionsISOMIR125B1 (Homo sapiens)6480464CTD[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNAPMID:24334028
Mir125b1multiple interactionsISOMir125b-1 (Mus musculus)6480464CTDARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]PMID:24334028
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