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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6decreases expressionISOIl6 (Rattus norvegicus)6480464CTDcarvedilol results in decreased expression of IL6 mRNA; carvedilol results in decreased expression of IL6 proteinPMID:16310260
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTDcarvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]PMID:10722803 PMID:11406463
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