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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10669
Species: Mus musculus
RGD Object: Gene
Symbol: Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:27166480464CTDcarvedilol results in increased expression of GNAS mRNA

PMID:20668454
multiple interactionsISORGD:7369166480464CTD[carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein

PMID:10455254
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.