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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10499
Species: Mus musculus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1decreases expressionISOEdn1 (Rattus norvegicus)6480464CTDcarvedilol results in decreased expression of EDN1 mRNAPMID:18971572
Edn1decreases expressionISOEDN1 (Homo sapiens)6480464CTDcarvedilol results in decreased expression of EDN1 mRNA; carvedilol results in decreased expression of EDN1 proteinPMID:9500873
Edn1decreases secretionISOEDN1 (Homo sapiens)6480464CTDcarvedilol results in decreased secretion of EDN1 proteinPMID:11078433
Edn1multiple interactionsISOEdn1 (Rattus norvegicus)6480464CTDcarvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]PMID:14711191
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDcarvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]PMID:16428915
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