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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Syn1
Name: synapsin I
Acc ID: CHEBI:34385
Term: 4-aminopyridine
Definition: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Chemical ID: MESH:D015761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Syn1increases expressionEXP 6480464CTD4-Aminopyridine results in increased expression of SYN1 protein modified form

PMID:28132918
Syn1multiple interactionsEXP 6480464CTD[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form] typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein]

PMID:28132918 PMID:33621091
Syn1affects response to substanceISORGD:113706480464CTDSYN1 protein affects the susceptibility to 4-Aminopyridine

PMID:22759588
Syn1increases response to substanceISORGD:113706480464CTDSYN1 results in increased susceptibility to 4-Aminopyridine

PMID:28132918
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