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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70970
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 1
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcs1increases expressionISOHmgcs1 (Mus musculus)6480464CTDbisphenol S results in increased expression of HMGCS1 mRNAPMID:34850234
Hmgcs1multiple interactionsISOHMGCS1 (Homo sapiens)6480464CTD[bisphenol S co-treated with Fulvestrant] results in decreased methylation of HMGCS1 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HMGCS1 mRNAPMID:28628672 PMID:31601247
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