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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68358
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acan
Name: aggrecan
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acanaffects methylationISOAcan (Mus musculus)6480464CTDbisphenol S affects the methylation of ACAN exon; bisphenol S affects the methylation of ACAN genePMID:31683443 PMID:33297965
Acandecreases methylationISOACAN (Homo sapiens)6480464CTDbisphenol S results in decreased methylation of ACAN genePMID:31601247
Acanmultiple interactionsISOACAN (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ACAN mRNAPMID:28628672
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