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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Thra
Name: thyroid hormone receptor alpha
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thradecreases expressionEXP 6480464CTDbisphenol S results in decreased expression of THRA mRNAPMID:28167136
Thraaffects bindingISOTHRA (Homo sapiens)6480464CTDbisphenol S binds to THRA proteinPMID:29146198
Thradecreases methylationISOThra (Mus musculus)6480464CTDbisphenol S results in decreased methylation of THRA genePMID:31683443
Thramultiple interactionsISOTHRA (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of THRA mRNA; bisphenol S inhibits the reaction [Triiodothyronine binds to THRA protein]PMID:28628672 PMID:29146198
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