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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2decreases expressionISOEsr2 (Mus musculus)6480464CTDbisphenol S results in decreased expression of ESR2 mRNAPMID:36310694
Esr2decreases expressionISOESR2 (Homo sapiens)6480464CTDbisphenol S results in decreased expression of ESR2 proteinPMID:34831106
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDbisphenol S results in increased activity of ESR2 proteinPMID:23714657 PMID:30582956
Esr2increases expressionISOEsr2 (Mus musculus)6480464CTDbisphenol S results in increased expression of ESR2 mRNAPMID:30196065
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDbisphenol S results in increased expression of ESR2 mRNA; bisphenol S results in increased expression of ESR2 proteinPMID:36565802 PMID:37234927
Esr2increases response to substanceISOEsr2 (Mus musculus)6480464CTDESR2 gene mutant form results in increased susceptibility to bisphenol SPMID:28903498
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDbisphenol S binds to and results in increased activity of ESR2 protein; bisphenol S results in increased activity of [ESR1 protein co-treated with ESR2 protein]; Fulvestrant inhibits the reaction [bisphenol S results in increased expression of ESR2 protein]PMID:22507746 PMID:27633901 PMID:33049310 PMID:36565802
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