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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDbisphenol S results in decreased activity of CAT proteinPMID:29940534 PMID:31424294
Catmultiple interactionsEXP 6480464CTD[bisphenol S co-treated with diethyl phthalate] results in decreased activity of CAT protein; morin inhibits the reaction [[bisphenol S co-treated with diethyl phthalate] results in decreased activity of CAT protein]PMID:35900689
Cataffects expressionISOCAT (Homo sapiens)6480464CTDbisphenol S affects the expression of CAT proteinPMID:31945527
Cataffects methylationISOCat (Mus musculus)6480464CTDbisphenol S affects the methylation of CAT genePMID:31683443
Catdecreases activityISOCat (Mus musculus)6480464CTDbisphenol S results in decreased activity of CAT proteinPMID:29199064 PMID:32742594
Catdecreases expressionISOCat (Mus musculus)6480464CTDbisphenol S results in decreased expression of CAT mRNA; bisphenol S results in decreased expression of CAT proteinPMID:29741722 PMID:36541330
Catdecreases methylationISOCat (Mus musculus)6480464CTDbisphenol S results in decreased methylation of CAT exonPMID:33297965
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTD[bisphenol S co-treated with cylindrospermopsin] results in decreased expression of CAT mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CAT mRNAPMID:28628672 PMID:32244372
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