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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of BAX mRNAPMID:36041667
Baxdecreases expressionISOBax (Mus musculus)6480464CTDbisphenol S results in decreased expression of BAX mRNAPMID:29741722
Baxincreases expressionISOBax (Mus musculus)6480464CTDbisphenol S results in increased expression of BAX mRNAPMID:32742594
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDbisphenol S results in increased expression of BAX proteinPMID:33749030 PMID:34186270
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD6,7-dihydroxyflavone inhibits the reaction [bisphenol S results in increased expression of BAX protein]; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BAX mRNAPMID:28628672 PMID:33749030
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