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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552733
Species: Mus musculus
RGD Object: Gene
Symbol: Pou5f1
Name: POU domain, class 5, transcription factor 1
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1decreases methylationEXP 6480464CTDbisphenol S results in decreased methylation of POU5F1 promoterPMID:33297965
Pou5f1increases expressionISOPOU5F1 (Homo sapiens)6480464CTDbisphenol S results in increased expression of POU5F1 mRNAPMID:36565802
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTD[bisphenol A co-treated with perfluorooctanoic acid co-treated with bisphenol S co-treated with perfluorooctane sulfonic acid] results in increased expression of POU5F1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of POU5F1 mRNAPMID:28628672 PMID:37834465
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