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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Adecreases methylationISOHspa1a (Mus musculus)6480464CTDbisphenol S results in decreased methylation of HSPA1A exonPMID:33297965
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDbisphenol S results in increased expression of HSPA1A mRNAPMID:37611474
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[bisphenol S co-treated with Tretinoin] results in increased expression of HSPA1A mRNAPMID:30951980
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